Novel Inhibitors of InhA Efficiently KillMycobacterium tuberculosisunder Aerobic and Anaerobic Conditions
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چکیده
منابع مشابه
Comparison of Nitroaromatic Compounds Metabolites Types by Sequencing Performance of Anaerobic-Aerobic and Aerobic-Anaerobic Processes
Introduction: Xenobiotic contamination is a global concern. Nitroaromatic compounds enter the environment through ammunition, ordnance disposal, burning the outdoors, and leakage of ammunition. Thirty percent of explosives enter the environment without any change, which can cause pollution of soil, water, and health concerns. So, effective remediation of the contaminated area is necessary. Mat...
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The siderophore production of the facultative anaerobe Pseudomonas stutzeri, strain CCUG 36651, grown under both aerobic and anaerobic conditions, was investigated by liquid chromatography and mass spectrometry. The bacterial strain has been isolated at a 626-m depth at the Aspö Hard Rock Laboratory, where experiments concerning the geological disposal of nuclear waste are performed. In bacteri...
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Previous work by this laboratory (Roth et al., 1955) has established that a definite aeration requirement existed for spore formation of Bacilus anthracis and Bacillu globigii. This aeration requirement was shown to be different at various stages of growth. In the case of spore germination of the aerobic organisms tested, the present work indicates that the necessity for aerobic conditions is c...
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The behavior of natural estrogens was examined by separately spiking 17β-estradiol (E2) and estrone (E1) into semicontinuous activated sludge reactors operated under aerobic, anaerobic and sequential anaerobic/aerobic conditions. Under aerobic and anaerobic conditions, E1 was formed from E2. The conversion of E1 to E2 was maximum conversion of E2 to E1 was higher than t E1 to E2. Overall, the d...
متن کاملDesigning Novel Inhibitors for Tuberculosis (Tb) by Targeting InhA and KasA Using Ligand Based Drug Design
Tuberculosis (TB) is a contagious disease caused by bacteria called Mycobacterium tuberculosis, infects an estimated nearly one third of the world population has latent tuberculosis infection, as it has been documented according to the World Health Organization. The emergence of multidrug resistant varieties of Mycobacterium tuberculosis has led to a search for novel drug targets. We have perfo...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2011
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00266-11